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NAMED ORGANIC REACTIONS

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FITTIG REACTION

* In Fittig reaction, two aryl halides are coupled in presence of sodium metal in dry ether or tetrahydrofuran to furnish biaryls.

Dry Ether
Ar-X  +  2Na  +  X-Ar  ----------------->   Ar-Ar + 2NaX  

Where Ar = aryl group, X = halogen

* The yields will be improved by using ultrasound, especially in two-phase reactions.

* A modification of reaction which involves, an alkyl halide and an aryl halide is called Wurtz-Fittig reaction.

* Refer Wurtz reaction for the reaction conditions and the detailed mechanism.

ILLUSTRATIONS

1) Biphenyl can be prepared by Fittig method as follows:

fittig reaction 1-1

 

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